Invention Grant
- Patent Title: Method of stabilizing antibody and stabilized solution-type antibody preparation
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Application No.: US10574016Application Date: 2004-10-01
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Publication No.: US08496930B2Publication Date: 2013-07-30
- Inventor: Yuji Ueno , Takashi Kayashita , Atsushi Ishihara , Masashi Nakakura , Kyoko Yamauchi
- Applicant: Yuji Ueno , Takashi Kayashita , Atsushi Ishihara , Masashi Nakakura , Kyoko Yamauchi
- Applicant Address: JP Tokyo
- Assignee: Kyowa Hakko Kirin Co., Ltd
- Current Assignee: Kyowa Hakko Kirin Co., Ltd
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2003-343645 20031001
- International Application: PCT/JP2004/014903 WO 20041001
- International Announcement: WO2005/033143 WO 20050414
- Main IPC: A61K39/395
- IPC: A61K39/395

Abstract:
The present invention provides a method of suppressing the formation of a soluble association of an antibody in a solution; a method of suppressing the formation of a chemically degraded product of an antibody in a solution; and a method of stabilizing an antibody in a solution. The present invention also provides a solution-type antibody preparation in which the formation of a soluble association is suppressed; a solution-type antibody preparation in which the formation of a chemically degraded product is suppressed; a solution-type antibody preparation in which the formation of a soluble association, the formation of a chemically degraded product and the formation of an insoluble aggregate are suppressed; an agent for suppressing the formation of a soluble association of an antibody; an agent for suppressing the formation of a chemically degraded product of an antibody; and a stabilizing agent for an antibody.
Public/Granted literature
- US20070020255A1 Method of stabilizing antibody and stabilized solution-type antibody preparation Public/Granted day:2007-01-25
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