Invention Grant
- Patent Title: Coating systems for the controlled delivery of hydrophilic bioactive agents
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Application No.: US12386469Application Date: 2009-04-17
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Publication No.: US08496954B2Publication Date: 2013-07-30
- Inventor: Ralph A. Chappa , Robert W. Hergenrother , Shannon A. Wadman , Klaus R. Wormuth
- Applicant: Ralph A. Chappa , Robert W. Hergenrother , Shannon A. Wadman , Klaus R. Wormuth
- Applicant Address: US MN Eden Prairie
- Assignee: Surmodics, Inc.
- Current Assignee: Surmodics, Inc.
- Current Assignee Address: US MN Eden Prairie
- Agency: Kagan Binder, PLLC
- Main IPC: A61F2/00
- IPC: A61F2/00 ; A61K9/50 ; A61K47/00 ; A61K38/00 ; A01N25/00

Abstract:
Described are coating systems for the controlled delivery of hydrophilic bioactive agents, for example, from implantable medical devices. The coating systems of the invention comprise (a) a polymeric basecoat layer containing one or more hydrophilic bioactive agents; and (b) an elution-controlling topcoat layer that comprises a poly(ethylene-co-vinyl acetate) copolymer. The elution rate of the hydrophilic bioactive agent can be controlled by varying the vinyl acetate concentration in the elution-controlling topcoat layer.
Public/Granted literature
- US20090280155A1 Coating systems for the controlled delivery of hydrophilic bioactive agents Public/Granted day:2009-11-12
Information query
IPC分类: