Invention Grant
- Patent Title: Process for the preparation of beta-lactam compounds
- Patent Title (中): 制备β-内酰胺化合物的方法
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Application No.: US12528695Application Date: 2008-03-10
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Publication No.: US08497088B2Publication Date: 2013-07-30
- Inventor: Thomas Van Der Does , Harold Monro Moody , Theodorus Johannes Godfried Maria Van Dooren
- Applicant: Thomas Van Der Does , Harold Monro Moody , Theodorus Johannes Godfried Maria Van Dooren
- Applicant Address: NL Delft
- Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
- Current Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
- Current Assignee Address: NL Delft
- Agency: Nixon & Vanderhye P.C.
- Priority: EP07103850 20070309
- International Application: PCT/EP2008/052809 WO 20080310
- International Announcement: WO2008/110527 WO 20080918
- Main IPC: C12P1/00
- IPC: C12P1/00
Abstract:
The present invention describes a process for the synthesis of a semi-synthetic β-lactam compound from a nucleus and a side chain selected from the group consisting of D-phenylglycine and D-dihydro-phenylglycine in the form of a side chain ester and an enzyme catalyzing the coupling of the side chain ester to the nucleus characterized in that the side chain ester is not isolated as a solid intermediate.
Public/Granted literature
- US20110104748A1 PROCESS FOR THE PREPARATION OF BETA-LACTAM COMPOUNDS Public/Granted day:2011-05-05
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