Invention Grant
US08497252B2 Compositions comprising cardiac stem cells overexpressing specific microRNAs and methods of their use in repairing damaged myocardium
有权
包含过表达特定microRNA的心脏干细胞的组合物及其在修复受损心肌中的用途
- Patent Title: Compositions comprising cardiac stem cells overexpressing specific microRNAs and methods of their use in repairing damaged myocardium
- Patent Title (中): 包含过表达特定microRNA的心脏干细胞的组合物及其在修复受损心肌中的用途
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Application No.: US13487974Application Date: 2012-06-04
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Publication No.: US08497252B2Publication Date: 2013-07-30
- Inventor: Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
- Applicant: Toru Hosoda , Piero Anversa , Annarosa Leri , Jan Kajstura
- Applicant Address: US NY Valhalla
- Assignee: New York Medical College
- Current Assignee: New York Medical College
- Current Assignee Address: US NY Valhalla
- Agency: Cooley LLP
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N5/02 ; A61K35/12
Abstract:
The invention provides compositions comprising modified stem cells containing a transgene that affects the expression of at least one gene that inhibits or promotes cardiomyogenesis. In particular, the invention discloses compositions comprising cardiac stem cells, wherein said cardiac stem cells comprise a transgene encoding a microRNA. The compositions of the invention find use in the treatment of cardiovascular disorders, such as myocardial infarction. Methods of repairing damaged myocardium in a subject using the modified stem cells are also disclosed.
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