Invention Grant
US08497281B2 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
有权
六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
- Patent Title: Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
- Patent Title (中): 六氢茚基吡啶和八氢苯并喹啉的芳基和杂芳基羰基衍生物
-
Application No.: US12940387Application Date: 2010-11-05
-
Publication No.: US08497281B2Publication Date: 2013-07-30
- Inventor: Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
- Applicant: Matthias Eckhardt , Stefan Peters , Herbert Nar , Frank Himmelsbach , Linghang Zhuang
- Applicant Address: US PA Fort Washington DE Ingelheim am Rhein
- Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- Current Assignee: Vitae Pharmaceuticals, Inc.,Boehringer Ingelheim International GmbH
- Current Assignee Address: US PA Fort Washington DE Ingelheim am Rhein
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Michael J. DeGrazia
- Priority: EP09175233 20091106
- Main IPC: C07D401/06
- IPC: C07D401/06 ; A61K31/352
Abstract:
The present invention relates to compounds defined by formula I wherein the variables R1, R2, R3, R4, and m are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.
Public/Granted literature
- US20110136800A1 ARYL-AND HETEROARYLCARBONYL DERIVATIVES OF HEXAHYDROINDENOPYRIDINE AND OCTAHYDROBENZOQUINOLINE Public/Granted day:2011-06-09
Information query
