Invention Grant
- Patent Title: Aminotetralin compounds as mu opioid receptor antagonists
- Patent Title (中): 氨基四氢萘化合物作为μ阿片受体拮抗剂
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Application No.: US13653652Application Date: 2012-10-17
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Publication No.: US08497287B2Publication Date: 2013-07-30
- Inventor: Michael R. Leadbetter , Sean G. Trapp , Daniel D. Long , John R. Jacobsen , Sabine Axt
- Applicant: Michael R. Leadbetter , Sean G. Trapp , Daniel D. Long , John R. Jacobsen , Sabine Axt
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Roberta P. Saxon
- Main IPC: A01N43/40
- IPC: A01N43/40 ; A01N43/42

Abstract:
The invention provides aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, n, and m are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.
Public/Granted literature
- US20130040965A1 AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS Public/Granted day:2013-02-14
Information query
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