Invention Grant
US08497294B2 Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases
有权
包含(S)-2-氨基-1-(4-氯苯基)-1- [4-(1H-吡唑-4-基) - 苯基] - 乙醇作为蛋白激酶调节剂的组合物
- Patent Title: Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases
- Patent Title (中): 包含(S)-2-氨基-1-(4-氯苯基)-1- [4-(1H-吡唑-4-基) - 苯基] - 乙醇作为蛋白激酶调节剂的组合物
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Application No.: US13180127Application Date: 2011-07-11
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Publication No.: US08497294B2Publication Date: 2013-07-30
- Inventor: Steven John Woodhead , David Charles Rees , Kyla Merriom Grimshaw
- Applicant: Steven John Woodhead , David Charles Rees , Kyla Merriom Grimshaw
- Applicant Address: GB Cambridge GB London GB London
- Assignee: Astex Therapeutics Limited,The Institute of Cancer Research: Royal Cancer Hospital,Cancer Research Technology Limtied
- Current Assignee: Astex Therapeutics Limited,The Institute of Cancer Research: Royal Cancer Hospital,Cancer Research Technology Limtied
- Current Assignee Address: GB Cambridge GB London GB London
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Priority: GB0704932.3 20070314
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07D231/12
![Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases](/abs-image/US/2013/07/30/US08497294B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides a composition comprising (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.
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