Invention Grant
US08497355B2 Anti-glypican-3 antibody having improved kinetics in plasma
有权
具有改善血浆动力学的抗磷脂酰肌醇蛋白聚糖-3抗体
- Patent Title: Anti-glypican-3 antibody having improved kinetics in plasma
- Patent Title (中): 具有改善血浆动力学的抗磷脂酰肌醇蛋白聚糖-3抗体
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Application No.: US12733933Application Date: 2008-09-26
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Publication No.: US08497355B2Publication Date: 2013-07-30
- Inventor: Tomoyuki Igawa , Taichi Kuramochi , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana , Takahiro Ishiguro
- Applicant: Tomoyuki Igawa , Taichi Kuramochi , Hirotake Shiraiwa , Hiroyuki Tsunoda , Tatsuhiko Tachibana , Takahiro Ishiguro
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Davidson, Davidson & Kappel, LLC
- Priority: JP2007-256063 20070928
- International Application: PCT/JP2008/002690 WO 20080926
- International Announcement: WO2009/041062 WO 20090402
- Main IPC: C07K16/30
- IPC: C07K16/30 ; A61K39/395 ; C07H21/04 ; C12P21/08 ; C12N15/13
Abstract:
A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient.
Public/Granted literature
- US20100239577A1 ANTI-GLYPICAN-3 ANTIBODY HAVING IMPROVED KINETICS IN PLASMA Public/Granted day:2010-09-23
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