Invention Grant
- Patent Title: Polyamine transporter selective compounds as anti-cancer agents
- Patent Title (中): 多胺转运蛋白选择性化合物作为抗癌剂
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Application No.: US12113540Application Date: 2008-05-01
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Publication No.: US08497398B1Publication Date: 2013-07-30
- Inventor: Otto Phanstiel, IV , Navneet Kaur
- Applicant: Otto Phanstiel, IV , Navneet Kaur
- Applicant Address: US FL Orlando
- Assignee: University of Central Florida Research Foundation, Inc.
- Current Assignee: University of Central Florida Research Foundation, Inc.
- Current Assignee Address: US FL Orlando
- Agency: Beusse, Wolter, Sanks, Mora & Maire, P.A.
- Agent Timothy H. Van Dyke
- Main IPC: C07C211/00
- IPC: C07C211/00 ; C09B11/02 ; A61K38/00 ; A61K47/00
Abstract:
Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.
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