Embodiments of a guided munition are provided, as are embodiments of a method for equipping a guided munition with an interlocking dome cover. In one embodiment, the guided munition includes a munition body, a seeker dome coupled to the munition body, and an interlocking dome cover. The interlocking dome cover includes a plurality of detachable dome cover sections collectively enclosing the seeker dome and a dome cover deployment device coupled to the plurality of detachable dome cover sections. When actuated, the dome cover deployment device initiates separation of the plurality of detachable dome cover sections to expose the seeker dome.