Invention Grant
US08497471B2 Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
有权
硫代嘌呤-S-甲基转移酶活性的质谱检测和由此产生的产物
- Patent Title: Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
- Patent Title (中): 硫代嘌呤-S-甲基转移酶活性的质谱检测和由此产生的产物
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Application No.: US13232861Application Date: 2011-09-14
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Publication No.: US08497471B2Publication Date: 2013-07-30
- Inventor: William F. Haddon , Nigel J. Clarke
- Applicant: William F. Haddon , Nigel J. Clarke
- Applicant Address: US DE Wilmington
- Assignee: Quest Diagnostics Investments Incorporated
- Current Assignee: Quest Diagnostics Investments Incorporated
- Current Assignee Address: US DE Wilmington
- Agency: Foley & Lardner LLP
- Main IPC: B01D59/44
- IPC: B01D59/44
Abstract:
Methods are described for measuring the amount of a methylation TPMT enzyme product in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying 6-MMP or isotopically labeled 6-MMP in a test sample utilizing mass spectrometric techniques and for using such methods to determine the activity of TPMT enzyme that is present in a sample.
Public/Granted literature
- US20120003676A1 MASS SPECTROMETRY ASSAY FOR THIOPURINE-S-METHYL TRANSFERASE ACTIVITY AND PRODUCTS GENERATED THEREBY Public/Granted day:2012-01-05
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