Aspects of a method and system for interference suppression between multipath signals utilizing a programmable interface suppression module may include one or more processors and/or circuits that are operable to program an interference suppression module based on one or more interference cancellation parameters. A plurality of weighting factor values may be determined based on the one or more interference suppression parameters and a received plurality of multipath signals. A plurality of estimated signals may be generated based on the plurality of weighting factor values. A plurality of updated estimated signals may be generated based on the plurality of estimated signals. A plurality of interference suppressed signals may be generated based on the plurality of updated estimated signals and/or a plurality of updated residual signals.