Transmission acknowledgement within multi-user wireless communication systems. Within multi-access wireless communication systems such as those operating in accordance with multi-user multiple input multiple output (MU-MIMO), orthogonal frequency division multiple access (OFDMA), and/or MU-MIMO/OFDMA, acknowledgement of receipt (e.g., using ACKs) is provided back to the sending or transmitting wireless communication device from each (or a subset) of the intended recipient wireless communication devices. Appropriate coordination of these ACKs from the respective, receiving wireless communication devices may be performed using instructions embedded within a multi-user packet that is provided to the receiving wireless communication devices. Alternatively, polling as effectuated by the sending or transmitting wireless communication device may be used to give explicit direction to the respective, receiving wireless communication devices of the manner by which their respective ACKs should be provided to the transmitting wireless communication device.