A packing box of wet wipes, which includes a body and a cover connected to the body. The cover includes: a cover body having a press button mounted therein, a top lid having a fastening part mounted thereon and mated with the press button, and a resilient connection part having a first end secured to a side of the top lid opposite to the fastening part and a second end protruding through a through hole of the top lid and secured to the cover body. The packing box of wet wipes of present invention has a simple structure, and can be used repeatedly and easy to open.