A surgical staple cartridge can comprise a cartridge housing having a longitudinal axis, the cartridge having a knife channel disposed along the longitudinal axis dividing the cartridge into a first side and a second side, a first, a second and a third row of staple pockets located on the first side of the cartridge housing having staples therein, wherein the first, the second and the third row of staple pockets are aligned parallel to the knife channel, a first fastener driver oriented to drive at least three fasteners out of the staple pockets in the first, the second and the third row of staple pockets, respectively, and a second fastener driver oriented to drive at least four fasteners out of the staple pockets in at least the second and third row of staple pockets, respectively.