A system for maintaining a desired cabin pressure in an aircraft includes a cabin-pressure control sub-system; a pressure relief valve for operation in event of failure or malfunction of the subsystem; a pressure relief valve actuator for operating the pressure relief valve; and a pressure relief valve control (PRVC) for producing commands for operation of the pressure relief valve actuator responsively to a first set of signal indicative of aircraft altitude and to presence of cabin-to-ambient pressure differential (ΔP) that varies from a desired ΔP by a predetermined amount.