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Invention Grant
US08501168B2 Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods 有权
细胞系，包含它们用于治疗黑素瘤的组合物，制备组合物的程序和治疗方法

Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods
Abstract:
Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human melanoma cell lines for the treatment of malignant diseases, wherein the cell lines are: (a) Mel-XY1 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2830), (b) Mel-XY2 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel-XY3 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829), or (e) sub-populations thereof. The cell lines may be irradiated, thus obtaining populations with apoptotic phenotype, and populations with necrotic phenotype of such lines. The compositions may comprise adjuvants and/or immuno-modifiers, and/or autologous dendritic cells.
Abstract(Chinese):

细胞系，包含它们用于治疗黑素瘤的组合物，制备组合物的程序和治疗方法。 更具体地，本发明涉及用于治疗恶性疾病的不同的人黑素瘤细胞系，其中细胞系是：（a）Mel-XY1（保藏于德国收藏的微生物和细胞培养物DSMZ，存取号DSM ACC2830），（ b）Mel-XY2（保藏于德国收藏的微生物和细胞培养物DSMZ，访问号DSM ACC2831），（c）Mel-XY3（保藏于德国收藏的微生物和细胞培养物DSMZ，存取号DSM ACC2832），（d） Mel-XX4（保藏于德国收藏的微生物和细胞培养物DSMZ，存取号码为DSM ACC2829），或（e）其亚群。 可以照射细胞系，从而获得具有凋亡表型的群体以及具有坏死表型的群体。 组合物可以包含佐剂和/或免疫改性剂，和/或自体树突状细胞。

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