Invention Grant
- Patent Title: Identification of TSH receptor autoantibodies using affinity-purified antibodies
- Patent Title (中): 使用亲和纯化抗体鉴定TSH受体自身抗体
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Application No.: US10536577Application Date: 2003-10-31
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Publication No.: US08501415B2Publication Date: 2013-08-06
- Inventor: Andreas Bergmann , Sabine Costagliola , Gilbert Vassart
- Applicant: Andreas Bergmann , Sabine Costagliola , Gilbert Vassart
- Applicant Address: DE Hennigsdorf
- Assignee: B.R.A.H.M.S. GmbH
- Current Assignee: B.R.A.H.M.S. GmbH
- Current Assignee Address: DE Hennigsdorf
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Priority: DE10255144 20021126
- International Application: PCT/EP03/12129 WO 20031031
- International Announcement: WO2004/048415 WO 20040610
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
The present invention relates to the use of affinity-purified polyclonal human autoantibodies against the TSH receptor (TSHR-Auto-Ab), obtained from the serum of Graves' disease patients and which have been purified to obtain biochemical homogeneity and comprise a specific activity of at least 1 IU/mg protein (human immunoglobulin). Also disclosed is the use of animal antibodies, which compete with the former for the binding sites of a functional human TSH receptor, as a specific binding reagent in an immunological determination method for the clinical identification of autoantibodies against the TSH receptor (TSHR-Auto-Ab) in a sample of a biological fluid of a patient to be examined for Graves' disease.
Public/Granted literature
- US20060165676A1 Identification of tsh receptor autoantibodies using affinity-purified antibodies Public/Granted day:2006-07-27
Information query
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