Invention Grant
- Patent Title: Indazole carboxamides and their use
- Patent Title (中): 吲唑甲酰胺及其用途
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Application No.: US11570060Application Date: 2005-06-24
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Publication No.: US08501780B2Publication Date: 2013-08-06
- Inventor: Jeffrey K. Kerns , Christine Edwards
- Applicant: Jeffrey K. Kerns , Christine Edwards
- Applicant Address: US PA Philadelphia
- Assignee: GlaxoSmithKline LLC
- Current Assignee: GlaxoSmithKline LLC
- Current Assignee Address: US PA Philadelphia
- Agent Nora L. Stein; Theodore R. Furman
- International Application: PCT/US2005/022870 WO 20050624
- International Announcement: WO2006/002434 WO 20060105
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D401/14

Abstract:
The invention is directed to novel indazole carboxamide derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1 and Z are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Public/Granted literature
- US20070281933A1 Novel Indazole Carboxamides And Their Use Public/Granted day:2007-12-06
Information query
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