Invention Grant
US08501782B2 Piperidinyl derivatives as modulators of chemokine receptor activity
有权
哌啶基衍生物作为趋化因子受体活性的调节剂
- Patent Title: Piperidinyl derivatives as modulators of chemokine receptor activity
- Patent Title (中): 哌啶基衍生物作为趋化因子受体活性的调节剂
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Application No.: US12670016Application Date: 2008-07-23
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Publication No.: US08501782B2Publication Date: 2013-08-06
- Inventor: Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
- Applicant: Daniel S. Gardner , John V. Duncia , John Hynes , T.G. Murali Dhar , Percy H. Carter , Joseph B. Santella
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Terence J. Bogie
- International Application: PCT/US2008/070801 WO 20080723
- International Announcement: WO2009/015164 WO 20090129
- Main IPC: A61K31/4545
- IPC: A61K31/4545 ; A61K31/454 ; A61K31/4525 ; A61K31/451 ; C07D405/12 ; C07D401/12 ; C07D401/04 ; C07D211/52
Abstract:
The present application describes modulators of MIP-1α of formula (I) or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, Q, T, W, Z, R1, R3, R4, R5, R5a and R5b, are as defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis using the modulators of formula (I) are disclosed.
Public/Granted literature
- US20100204274A1 PIPERIDINYL DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Public/Granted day:2010-08-12
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