Invention Grant
US08501791B2 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators
失效
作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
- Patent Title: 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators
- Patent Title (中): 作为黑皮质素受体调节剂的1,2,4-噻二唑衍生物
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Application No.: US12835220Application Date: 2010-07-13
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Publication No.: US08501791B2Publication Date: 2013-08-06
- Inventor: Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
- Applicant: Magdalena Eisinger , Louis J. Fitzpatrick , Daniel H. Lee , Kevin Pan , Carlos Plata-Salaman , Allen B. Reitz , Virginia L. Smith-Swintosky , Boyu Zhao
- Applicant Address: US NJ Raritan
- Assignee: Ortho-McNeil Pharamaceutical, Inc.
- Current Assignee: Ortho-McNeil Pharamaceutical, Inc.
- Current Assignee Address: US NJ Raritan
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Main IPC: A61K31/433
- IPC: A61K31/433 ; C07D285/08
Abstract:
The present invention is directed to novel 1,2,4-thiadiazol-2-ium derivatives useful as agonists or antagonists of the melanocortin receptor. More particularly, the compounds of the present invention are useful for the treatment of metabolic, CNS and dermatological disorders such as obesity, impaired oral glucose tolerance, elevated blood glucose levels, type II diabetes, Syndrome X, diabetic retinopathy, spinal cord injury, nerve injury, acute neurodegenerative disorders, chronic neurodegenerative disorders, plexopathies, male erectile dysfunction, dry eyes, acne, dry skin, aged skin, seborrheic dermatitis, rosacea, excessive ear wax, meibomian gland disorder, pseudofolliculitis, yeast infections, dandruff, hidradenitis suppurativa, ocular rosacea and eccrine gland disorder.
Public/Granted literature
- US20100280079A1 0NOVEL, 1,2,4-THIADIAZOLIUM DERIVATIVES AS MELANOCORTIN RECEPTOR MODULATORS Public/Granted day:2010-11-04
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