Invention Grant
US08501795B2 (3-aryl-1H-1,2,4-triazol-5-yl)-linked heterocycle derivatives
有权
（3-芳基-1H-1,2,4-三唑-5-基） - 连接的杂环衍生物
- Patent Title: (3-aryl-1H-1,2,4-triazol-5-yl)-linked heterocycle derivatives
- Patent Title (中): （3-芳基-1H-1,2,4-三唑-5-基） - 连接的杂环衍生物
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Application No.: US13515351Application Date: 2010-12-15
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Publication No.: US08501795B2Publication Date: 2013-08-06
- Inventor: Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
- Applicant: Ask Püschl , Jacob Nielsen , Jan Kehler , John Paul Kilburn , Mauro Marigo , Morten Langgård
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agent Mary Catherine Di Nunzio; Kitae T. Lim
- Priority: DKPA200901340 20091217
- International Application: PCT/DK2010/050344 WO 20101215
- International Announcement: WO2011/072697 WO 20110623
- Main IPC: A61K31/41
- IPC: A61K31/41
Abstract:
This invention is directed to compounds of formula I having the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
Public/Granted literature
- US20120309764A1 Heteroaromatic aryl triazole derivatives as PDE10A enzyme inhibitors Public/Granted day:2012-12-06
Information query
