Invention Grant
- Patent Title: Dual-acting antihypertensive agents
- Patent Title (中): 双作用抗高血压药
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Application No.: US13527306Application Date: 2012-06-19
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Publication No.: US08501798B2Publication Date: 2013-08-06
- Inventor: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Robert Murray McKinnell
- Applicant: Paul Allegretti , Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Robert Murray McKinnell
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/4164
- IPC: A61K31/4164 ; C07D233/54
Abstract:
The invention relates to compounds having the formula: wherein: Q, W, Y, Z, r, and Ar are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20120258992A1 DUAL-ACTING ANTIHYPERTENSIVE AGENTS Public/Granted day:2012-10-11
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