Invention Grant
- Patent Title: γ-secretase inhibitor
- Patent Title (中): γ-分泌酶抑制剂
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Application No.: US12672326Application Date: 2008-07-01
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Publication No.: US08501813B2Publication Date: 2013-08-06
- Inventor: Atsuhiro Abe , Hideaki Shimizu , Seigo Sawada , Hiroshi Kodaira
- Applicant: Atsuhiro Abe , Hideaki Shimizu , Seigo Sawada , Hiroshi Kodaira
- Applicant Address: JP Tokyo
- Assignee: Kabushiki Kaisha Yakult Honsha
- Current Assignee: Kabushiki Kaisha Yakult Honsha
- Current Assignee Address: JP Tokyo
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2007-207521 20070809
- International Application: PCT/JP2008/001728 WO 20080701
- International Announcement: WO2009/019815 WO 20090212
- Main IPC: A01N37/18
- IPC: A01N37/18 ; A61K31/16 ; C07C233/00 ; C07C235/00 ; C07C237/00 ; C07C239/00

Abstract:
It is intended to provide a novel compound that has an excellent γ-secretase inhibitory effect and specifically inhibits Aβ production.The present invention provides a compound of the following formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents a linear or branched alkyl group having 1 to 4 carbon atoms or a phenyl group; R2 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more phenyl or halogenophenyl groups; R3 represents a linear or branched alkyl group having 1 to 4 carbon atoms which may be substituted by one or more hydroxyl groups; R4 represents a linear or branched alkyl group having 1 to 4 carbon atoms; and the symbol “*” represents a chiral center.
Public/Granted literature
- US20110071224A1 NOVEL GAMMA-SECRETASE INHIBITOR Public/Granted day:2011-03-24
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