Invention Grant
US08501907B2 Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
有权
免疫球蛋白裂解片段作为疾病指标和用于检测和结合的组合物
- Patent Title: Immunoglobulin cleavage fragments as disease indicators and compositions for detecting and binding such
- Patent Title (中): 免疫球蛋白裂解片段作为疾病指标和用于检测和结合的组合物
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Application No.: US12950240Application Date: 2010-11-19
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Publication No.: US08501907B2Publication Date: 2013-08-06
- Inventor: Robert Jordan , David Knight , Randall Brezski , Mary Ryan , Diane Petrone
- Applicant: Robert Jordan , David Knight , Randall Brezski , Mary Ryan , Diane Petrone
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agent Kenneth J. Dow
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K14/00

Abstract:
The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.
Public/Granted literature
- US20110076264A1 IMMUNOGLOBULIN CLEAVAGE FRAGMENTS AS DISEASE INDICATORS AND COMPOSITIONS FOR DETECTING AND BINDING SUCH Public/Granted day:2011-03-31
Information query
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