Invention Grant
- Patent Title: Tetomilast polymorphs
- Patent Title (中): 替托司特多晶型物
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Application No.: US12086587Application Date: 2007-03-15
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Publication No.: US08501949B2Publication Date: 2013-08-06
- Inventor: Satoshi Aoki , Kenji Nakaya , Masahiro Sota , Masashi Ishigami
- Applicant: Satoshi Aoki , Kenji Nakaya , Masahiro Sota , Masashi Ishigami
- Applicant Address: JP Tokyo
- Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee: Otsuka Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- Priority: JP2006-075307 20060317
- International Application: PCT/JP2007/055931 WO 20070315
- International Announcement: WO2007/119496 WO 20071025
- Main IPC: C07D417/04
- IPC: C07D417/04

Abstract:
The present invention provides a tetomilast crystal that is industrially easily produced in a large volume. (1) a tetomilast hydrate crystal having a powder X-ray diffraction spectrum that is substantially the same as the powder X-ray diffraction spectrum shown in FIG. 2; (2) an anhydrous tetomilast type A crystal having a powder X-ray diffraction spectrum that is substantially the same as the powder X-ray diffraction spectrum shown in FIG. 4; (3) an anhydrous tetomilast type C crystal having a powder X-ray diffraction spectrum that is substantially the same as the powder X-ray diffraction spectrum shown in FIG. 8; (4) a tetomilast acetonitrile solvate crystal having a powder X-ray diffraction spectrum that is substantially the same as the powder X-ray diffraction spectrum shown in FIG. 10; and (5) a mixture consisting of the above anhydrous tetomilast type A crystal and an anhydrous tetomilast type B crystal. These crystals are stable towards heat and moisture, and are also excellent in terms of the disintegration property and dissolution property of tablets. Accordingly, these crystals are preferably used as pharmaceutical compositions.
Public/Granted literature
- US20100222590A1 Tetomilast Polymorphs Public/Granted day:2010-09-02
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