Invention Grant
- Patent Title: Method for the production of a single heavy chain antibody
- Patent Title (中): 生产单重重链抗体的方法
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Application No.: US12833132Application Date: 2010-07-09
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Publication No.: US08502014B2Publication Date: 2013-08-06
- Inventor: Frank Grosveld
- Applicant: Frank Grosveld
- Applicant Address: NL
- Assignee: Erasmus Universiteit Rotterdam
- Current Assignee: Erasmus Universiteit Rotterdam
- Current Assignee Address: NL
- Agency: Saul Ewing LLP
- Agent Doreen Y. Trujillo
- Priority: GB0110029.6 20010424
- Main IPC: C12P21/00
- IPC: C12P21/00 ; A01K67/027
Abstract:
The present invention relates to a method for the generation of single chain immunoglobulins in a mammal. In particular, the present invention relates to a method for the generation of single chain camelid VHH antibodies in a mammal which undergo the process of class-switching and affinity maturation found within antibody producing B cells. Single chain antibodies generated using the method of the present invention and the uses thereof are also described.
Public/Granted literature
- US20110004949A1 IMMUNOGLOBULIN 1 Public/Granted day:2011-01-06
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