According to one aspect, the subject matter described herein includes a method for providing Diameter application loop prevention. The method includes steps occurring at a first Diameter node. The method further includes receiving a first Diameter message that is to be sent to a destination. The method also includes determining whether the first Diameter message requires processing by a Diameter application. The method includes, in response to determining that the first Diameter message requires processing by the Diameter application, determining whether the first Diameter message has been processed by the Diameter application. The method further includes, in response to determining that the first Diameter message has been processed by the Diameter application, preventing the first Diameter message from being sent to the Diameter application for processing.