Disclosed are methods, computer program products, apparatus, and systems for sending and receiving uniform serial bus (“USB”) messages between a host computer and a USB device over a data network, using a USB server in communication with the data network and the host computer, and a USB client in communication with the data network and the USB device. An association is established between the USB server and the USB client. The USB server receives a first USB message from the host computer. The first USB message is translated to a format suitable for sending over the data network, and sent as a first network message from the USB server to the USB client over the data network. The USB server receives a second network message from the USB client over the data network, and translates the second network message to a USB format.