The present solution provides techniques that may accelerate and optimize network traffic in the areas of proxy caching, protocol acceleration, domain name resolution acceleration, and compression improvements using prefetching and/or prefreshening techniques to improve intermediary caching. Techniques described herein may improve the efficiency of obtaining and servicing data from originating servers to requesting clients and accelerates domain name resolution. The present solution may further help accelerate resolution of URLs into IP addresses. The present solution may improve compression techniques by prefetching non-cacheable and cacheable content to use for compressing network traffic, such as HTTP. The acceleration and optimization techniques described herein may be deployed on the client as a client agent or as part of a browser, as well as on any type and form of intermediary device, such as an appliance, proxying device or any type of interception caching and/or proxying device.