A system for scanning a file for malicious codes may include a client agent running in a client computer and a scan server running in a server computer, the client computer and the server computer communicating over a computer network. The client agent may be configured to locally receive a scan request to scan a target file for malicious codes and to communicate with the scan server to scan the target file using a scan engine running in the server computer. The scan server in communication with the client agent allows the scan engine to scan the target file by issuing file I/O requests to access the target file located in the client computer. The client agent may be configured to check for digital signatures and to maintain a file cache of previously scanned files to minimize network traffic.