Invention Grant
- Patent Title: Compounds having affinity for amyloid
- Patent Title (中): 对淀粉样蛋白具有亲和性的化合物
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Application No.: US13537422Application Date: 2012-06-29
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Publication No.: US08506930B2Publication Date: 2013-08-13
- Inventor: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- Applicant Address: JP Tokyo
- Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee: Nihon Medi-Physics Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Fitch, Even, Tabin & Flannery, LLP
- Priority: JP2006-140044 20060519; JP2006-324701 20061130
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14

Abstract:
The present invention provides a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagencity. Provided is a compound represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a halogen substituent; R2 is a halogen substituent; and m is an integer of 0 to 2, provided that at least one of R1 and R2 is a radioactive halogen substituent, at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4 as well as a low-toxic diagnostic agent comprising a compound represented by the preceding formula or a salt thereof.
Public/Granted literature
- US20120271053A1 NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID Public/Granted day:2012-10-25
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