Invention Grant
US08506932B2 Tetracyclic indole derivatives as in vivo imaging agents and having peripheralbenzodiazepine receptor affinity (PBR)
有权
四环吲哚衍生物作为体内显像剂并具有外周苯并二氮杂受体亲和力（PBR）
- Patent Title: Tetracyclic indole derivatives as in vivo imaging agents and having peripheralbenzodiazepine receptor affinity (PBR)
- Patent Title (中): 四环吲哚衍生物作为体内显像剂并具有外周苯并二氮杂受体亲和力（PBR）
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Application No.: US12094172Application Date: 2006-11-20
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Publication No.: US08506932B2Publication Date: 2013-08-13
- Inventor: Erik Arstad , Ian Wilson , Sajinder Kaur Luthra , Frank Brady , Bengt Langstrom , Farhad Karimi , Edward George Robins , Bo Shan
- Applicant: Erik Arstad , Ian Wilson , Sajinder Kaur Luthra , Frank Brady , Bengt Langstrom , Farhad Karimi , Edward George Robins , Bo Shan
- Applicant Address: GB London
- Assignee: Hammersmith Imanet Limited
- Current Assignee: Hammersmith Imanet Limited
- Current Assignee Address: GB London
- Agent Robert F. Chisholm
- Priority: GB0523506.4 20051118
- International Application: PCT/GB2006/004342 WO 20061120
- International Announcement: WO2007/057705 WO 20070524
- Main IPC: A61K49/00
- IPC: A61K49/00
Abstract:
The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.
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