Provided is artificial saliva including hyaluronic acid (HA) comprising 0.4 to 0.6 mg/ml of hyaluronic acid (HA), based on 100 parts by weight of the HA, 10 to 12 parts by weight of lysozyme, and 7 to 9 parts by weight of peroxidase. The artificial saliva may be used to treat xerostomia or oral candidiasis and can be effectively used to prevent or treat complications cased by reduced secretion of saliva, since the artificial saliva is in a physiological range of human saliva and shows adequate antimicrobial activities.