Invention Grant
- Patent Title: Compressed tablets comprising microcapsules with modified release
- Patent Title (中): 包含经释放的微胶囊的压片
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Application No.: US10507886Application Date: 2003-03-14
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Publication No.: US08507003B2Publication Date: 2013-08-13
- Inventor: Rafaël Jorda , Pierre Autant
- Applicant: Rafaël Jorda , Pierre Autant
- Applicant Address: FR
- Assignee: Flamel Technologies
- Current Assignee: Flamel Technologies
- Current Assignee Address: FR
- Agency: Patton Boggs LLP
- Priority: FR0203336 20020318
- International Application: PCT/FR03/00827 WO 20030314
- International Announcement: WO03/077888 WO 20030925
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/22 ; A61K9/16

Abstract:
A multi(micro)particulate tablet is provided comprising microparticles which comprise a mechanically non-deformable core of active principle (AP). The tablet is formed from reservoir microcapsules with prolonged release of the AP, which are each made up of a non-deformable core comprising AP and covered with at least one film coating controlling release of the AP in vivo. The microcapsules have a particle size of between 50 and 1000 microns and are coated with at least one outer overcoating envelope comprising at least one deformable organic constituent having a melting point of between 40° C. and 120° C. The envelope allows the prolonged release of the AP in vivo without modification of the release profile when the microcapsules are compressed to form a tablet, even for microparticles not specifically formulated for compression.
Public/Granted literature
- US20050266078A1 Compressed tablets comprising microcapsules with modified release Public/Granted day:2005-12-01
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