Invention Grant
US08507221B2 Process for the expression of peptides of interest using GCSF as a fusion partner
有权
使用GCSF作为融合配偶体表达目的肽的方法
- Patent Title: Process for the expression of peptides of interest using GCSF as a fusion partner
- Patent Title (中): 使用GCSF作为融合配偶体表达目的肽的方法
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Application No.: US12679346Application Date: 2008-09-22
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Publication No.: US08507221B2Publication Date: 2013-08-13
- Inventor: Sanjeev Kumar Mendiretta , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
- Applicant: Sanjeev Kumar Mendiretta , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
- Applicant Address: IN Ahmedabad
- Assignee: Cadila Healthcare Limited
- Current Assignee: Cadila Healthcare Limited
- Current Assignee Address: IN Ahmedabad
- Agency: Ladas & Parry LLP
- Priority: IN1848/MUM/2007 20070921
- International Application: PCT/IN2008/000599 WO 20080922
- International Announcement: WO2009/066320 WO 20090528
- Main IPC: C07K14/535
- IPC: C07K14/535 ; C07K14/62 ; C07K14/635 ; C12P21/02
Abstract:
The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
Public/Granted literature
- US20120142891A1 FUSION PROTEIN SYSTEMS SUITABLE FOR HIGH EXPRESSION OF PEPTIDES Public/Granted day:2012-06-07
Information query
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