Invention Grant
US08507449B2 Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan
失效
结晶D-异谷氨酰-D-色氨酸和D-异谷氨酰-D-色氨酸的单铵盐
- Patent Title: Crystalline D-isoglutamyl-D-tryptophan and the mono ammonium salt of D-isoglutamyl-D-tryptophan
- Patent Title (中): 结晶D-异谷氨酰-D-色氨酸和D-异谷氨酰-D-色氨酸的单铵盐
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Application No.: US13400303Application Date: 2012-02-20
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Publication No.: US08507449B2Publication Date: 2013-08-13
- Inventor: Tim Fat Tam , Blaise N'Zemba , Regis Leung-Toung , Yingsheng Wang , Yanqing Zhao , Lily Yu
- Applicant: Tim Fat Tam , Blaise N'Zemba , Regis Leung-Toung , Yingsheng Wang , Yanqing Zhao , Lily Yu
- Applicant Address: CA Toronto, ON
- Assignee: Apotex Technologies Inc.
- Current Assignee: Apotex Technologies Inc.
- Current Assignee Address: CA Toronto, ON
- Agency: Sim & McBurney
- Priority: CA2569204 20061128
- Main IPC: C07K5/072
- IPC: C07K5/072 ; A61K38/05
Abstract:
A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D-tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D-isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1:1) is a stable pharmaceutical solid.
Public/Granted literature
- US20130060048A1 CRYSTALLINE D-ISOGLUTAMYL-D-TRYPTOPHAN AND THE MONO AMMONIUM SLAT OF D-ISOGLUTAMYL-D-TRYPTOPHAN Public/Granted day:2013-03-07
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