Invention Grant
US08507477B2 3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
有权
具有N-连接的杂环CGRP受体拮抗剂的3-和6-喹啉
- Patent Title: 3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
- Patent Title (中): 具有N-连接的杂环CGRP受体拮抗剂的3-和6-喹啉
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Application No.: US13059164Application Date: 2009-08-14
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Publication No.: US08507477B2Publication Date: 2013-08-13
- Inventor: Michael R. Wood , Ian M. Bell , June J. Kim , Harold G. Selnick , Craig A. Stump
- Applicant: Michael R. Wood , Ian M. Bell , June J. Kim , Harold G. Selnick , Craig A. Stump
- Applicant Address: US NJ Rahway
- Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee: Merck, Sharp & Dohme, Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; Gerard M. Devlin
- International Application: PCT/US2009/053804 WO 20090814
- International Announcement: WO2010/021919 WO 20100225
- Main IPC: C07D487/10
- IPC: C07D487/10 ; A61K31/55 ; A61P25/06
Abstract:
Compounds of Formula (I): (where variables R1A, R1B, R2, R3, R4, A, and Z are as defined herein) which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP receptors are involved.
Public/Granted literature
- US20110306604A1 3- AND 6-QUINOLINES WITH N-ATTACHED HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS Public/Granted day:2011-12-15
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