The invention relates to a multi-application robotized platform for neurosurgery, comprising: a planning console comprising processing means that can especially receive and process digital images; a positioning robot arm comprising a plurality of arm segments, one of which is terminal and proximal and the other is terminal and distal, said segments being interconnected by articulated elements, the terminal distal arm segment comprising a receiving element arranged in such a way as to receive tools, and the robot arm being guided by the planning console; at least one video image recording means able to record images of the anatomical region to be processed, said means being electrically connectable to the processing means of the planning console, and able to be positioned and fixed to the receiving element of the distal arm segment in a removable manner; tools, instruments and others suitable for being positioned and fixed to the receiving element of the terminal distal arm segment in a removable manner; means for observing pre-operating and per-operating images, said means being electrically connected to the planning console for receiving video signals therefrom relating to the images to be displayed, and/or to the image recording means. The invention also relates to a method ensuring an improved resetting of the anatomical region to be processed in relation to its digital model using said platform.