The present disclosure is generally directed to identifying and/or analyzing high resolution variations in a measured physiologic parameter, such as blood oxygen saturation (SpO2) measured using pulse oximetry. Present embodiments may include a system including a sensor comprising an emitter capable of emitting light at different wavelengths into a tissue bed, and a detector capable of detecting the light from the emitter after dispersion and/or reflection by the tissue bed. Further, the system may include a pulse oximeter capable of receiving signals from the sensor that are indicative of characteristics of the light detected by the detector, and utilizing the signals to estimate blood oxygen saturation values over time at a high resolution to facilitate detection of variations in the blood oxygen saturation values that are smaller in magnitude than an accuracy, display precision, and/or calibration of the blood oxygen saturation values.