Methods, systems, and computer program products for implementing a real-time, user configurable, debugging framework for use in debugging applications. A method includes executing an application on a computer, the application comprising a plurality of instructions including a debug macro instruction. The debug macro instruction is associated with a set of parameters for describing one or both of system and application conditions. The method also includes specifying one or more trigger criteria, the trigger criteria comprising a set of dynamic values for the set of parameters. The method further performing, while the application is executing, executing the debug macro instruction, detecting whether the trigger criteria have been met by the application, the detecting in response to executing the debug macro instruction, and upon detecting that the trigger criteria have been met, initiating a debugging session in response to the detecting.