In certain embodiments, a method includes receiving a first file. The method also includes accessing at least one storage module comprising a first malware pattern, a second malware pattern, and a third malware pattern. The second malware pattern is a first permutation of the first malware pattern. The third malware pattern is a second permutation of the second malware pattern and is different than the second malware pattern. The method includes comparing, by at least one processor, the first file to the third malware pattern. In addition, the method includes determining, by the at least one processor, that the first file comprises malware in response to comparing the file to the third malware pattern.