Invention Grant
US08524476B2 Bacterium producing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity and a method for manufacturing the product
有权
产生由具有2-氧戊二酸依赖性酶活性的蛋白质催化的反应产物的细菌和制备该产物的方法
- Patent Title: Bacterium producing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity and a method for manufacturing the product
- Patent Title (中): 产生由具有2-氧戊二酸依赖性酶活性的蛋白质催化的反应产物的细菌和制备该产物的方法
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Application No.: US12819485Application Date: 2010-06-21
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Publication No.: US08524476B2Publication Date: 2013-09-03
- Inventor: Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Olga Sergeevna Beznoschenko , Tatyana Aleksandrovna Bachina , Yuki Imabayashi , Masakazu Sugiyama , Shunichi Suzuki
- Applicant: Sergey Vasilievich Smirnov , Natalia Nikolaevna Samsonova , Veronika Aleksandrovna Kotliarova , Natalia Yurievna Rushkevich , Olga Sergeevna Beznoschenko , Tatyana Aleksandrovna Bachina , Yuki Imabayashi , Masakazu Sugiyama , Shunichi Suzuki
- Applicant Address: JP Tokyo
- Assignee: Ajinomoto Co., Inc.
- Current Assignee: Ajinomoto Co., Inc.
- Current Assignee Address: JP Tokyo
- Agency: Cermak Nakajima LLP
- Agent Shelly Guest Cermak
- Priority: RU2007147436 20071221
- Main IPC: C12N9/02
- IPC: C12N9/02 ; C12N1/20 ; C12N15/00 ; C12P13/06 ; C12P1/04 ; C07H21/04
Abstract:
A method for manufacturing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity such as (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using a bacterium transformed with a DNA fragment containing a gene coding for a protein having 2-oxoglutarate-dependent enzyme activity such as L-isoleucine dioxygenase activity; and wherein said bacterium has the ability to produce a product such as (2S,3R,4S)-4-hydroxy-L-isoleucine.
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