Invention Grant
US08524485B2 Long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-CoA lysophospholipid acyltransferases
有权
通过表达酰基辅酶A溶血磷脂酰基转移酶的长链ω-3和ω-6多不饱和脂肪酸生物合成
- Patent Title: Long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-CoA lysophospholipid acyltransferases
- Patent Title (中): 通过表达酰基辅酶A溶血磷脂酰基转移酶的长链ω-3和ω-6多不饱和脂肪酸生物合成
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Application No.: US12814764Application Date: 2010-06-14
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Publication No.: US08524485B2Publication Date: 2013-09-03
- Inventor: Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
- Applicant: Narendra S. Yadav , Hongxiang Zhang , Quinn Qun Zhu
- Applicant Address: US DE Wilmington
- Assignee: E I du Pont de Nemours and Company
- Current Assignee: E I du Pont de Nemours and Company
- Current Assignee Address: US DE Wilmington
- Main IPC: C12N1/00
- IPC: C12N1/00 ; C12N1/10 ; C12N15/00 ; C07H21/04 ; A23D9/00
Abstract:
Methods for increasing C18 to C20 elongation conversion efficiency and/or Δ4 desaturation conversion efficiency in long-chain polyunsaturated fatty acid [“LC-PUFA”]-producing recombinant oleaginous microbial host cells are provided herein, based on over-expression of acyl-CoA:lysophospholipid acyltransferases [“LPLATs”] (e.g., Ale1, LPAAT, LPCAT). Production host cells and oils produced by the methods of the invention are also claimed.
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