Invention Grant
- Patent Title: Methods and compositions for homologous recombination in human cells
- Patent Title (中): 人类细胞中同源重组的方法和组合物
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Application No.: US12791696Application Date: 2010-06-01
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Publication No.: US08524498B2Publication Date: 2013-09-03
- Inventor: Niels Geijsen , Christa Buecker
- Applicant: Niels Geijsen , Christa Buecker
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Mark J. FitzGerald
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N5/071 ; C12N5/02
Abstract:
The methods and compositions described herein are based, in part, on the discovery of a stem cell state in human cells that resembles the morphology observed in murine-derived stem cells. Induction of such a state in human stem cells permits an increase in the efficiency of homologous recombination. Thus, the methods and compositions described herein relate to cells and methods for increasing the efficiency of homologous recombination in human stem cells.
Public/Granted literature
- US20100304489A1 METHODS AND COMPOSITIONS FOR HOMOLOGOUS RECOMBINATION IN HUMAN CELLS Public/Granted day:2010-12-02
Information query
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