Invention Grant
- Patent Title: High potency siRNAS for reducing the expression of target genes
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Application No.: US12550625Application Date: 2009-08-31
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Publication No.: US08524680B2Publication Date: 2013-09-03
- Inventor: David Brown , Lance P. Ford , Richard A. Jarvis , Vince Pallotta , Brittan L. Pasloske
- Applicant: David Brown , Lance P. Ford , Richard A. Jarvis , Vince Pallotta , Brittan L. Pasloske
- Applicant Address: US CA Carlsbad
- Assignee: Applied Biosystems, LLC
- Current Assignee: Applied Biosystems, LLC
- Current Assignee Address: US CA Carlsbad
- Main IPC: C12N15/11
- IPC: C12N15/11
Abstract:
The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.
Public/Granted literature
- US20100221789A1 HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES Public/Granted day:2010-09-02
Information query
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