Invention Grant
US08524712B2 Triazinone and diazinone derivatives useful as HSP90 inhibitors
有权
三嗪酮和二嗪酮衍生物可用作HSP90抑制剂
- Patent Title: Triazinone and diazinone derivatives useful as HSP90 inhibitors
- Patent Title (中): 三嗪酮和二嗪酮衍生物可用作HSP90抑制剂
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Application No.: US12593147Application Date: 2008-03-24
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Publication No.: US08524712B2Publication Date: 2013-09-03
- Inventor: Chi-Wan Lee , Teresa Przewloka , Weiwen Ying , Minghu Song , Zhenjian Du , Kevin Foley , Dan Zhou , Shuzhen Qin
- Applicant: Chi-Wan Lee , Teresa Przewloka , Weiwen Ying , Minghu Song , Zhenjian Du , Kevin Foley , Dan Zhou , Shuzhen Qin
- Applicant Address: US MA Lexington
- Assignee: Synta Pharmaceuticals Corp.
- Current Assignee: Synta Pharmaceuticals Corp.
- Current Assignee Address: US MA Lexington
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- International Application: PCT/US2008/003810 WO 20080324
- International Announcement: WO2008/118391 WO 20081002
- Main IPC: A61K31/53
- IPC: A61K31/53 ; A61K31/519 ; A61K31/47 ; C07D401/04 ; C07D253/06 ; C07D471/02 ; C07D487/02
Abstract:
The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a compound of the invention, or a composition comprising such a compound.
Public/Granted literature
- US20100298331A1 TRIAZINONE AND DIAZINONE DERIVATIVES USEFUL AS HSP90 INHIBITORS Public/Granted day:2010-11-25
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