Invention Grant
US08524714B2 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
有权
作为聚（ADP-核糖）聚合酶抑制剂的7-苯基烷基取代的2-喹啉酮和2-喹喔啉酮
- Patent Title: 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors
- Patent Title (中): 作为聚（ADP-核糖）聚合酶抑制剂的7-苯基烷基取代的2-喹啉酮和2-喹喔啉酮
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Application No.: US13047402Application Date: 2011-03-14
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Publication No.: US08524714B2Publication Date: 2013-09-03
- Inventor: Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- Applicant: Dominique Jean-Pierre Mabire , Jerome Emile Georges Guillemont , Jacobus Alphonsus Josephus van Dun , Maria Victorina Francisca Somers , Walter Boudewijn Leopold Wouters
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica, NV
- Current Assignee: Janssen Pharmaceutica, NV
- Current Assignee Address: BE
- Priority: EP03078650 20031120
- Main IPC: A61K31/498
- IPC: A61K31/498 ; C07D401/06
Abstract:
The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, R1, R2, R3, R4, R5, R6 and X have defined meanings.
Public/Granted literature
- US20110230492A1 7-PHENYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS Public/Granted day:2011-09-22
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