Invention Grant
- Patent Title: Therapeutic compounds for blocking DNA synthesis of pox viruses
- Patent Title (中): 用于阻断痘病毒DNA合成的治疗化合物
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Application No.: US13590667Application Date: 2012-08-21
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Publication No.: US08524719B2Publication Date: 2013-09-03
- Inventor: Robert P. Ricciardi
- Applicant: Robert P. Ricciardi
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Pearl Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- Main IPC: A61K31/519
- IPC: A61K31/519
Abstract:
This invention provides methods of inhibiting replication of a poxvirus by contacting a poxvirus with a compound having formula I, formula XXI, formula XXXII, or formula XLI which in turn reduce, inhibit, or abrogate poxvirus DNA polymerase activity and/or its interaction with its processivity factor. Formula I, formula XXI, formula XXXII, or formula XLI can be utilized to treat humans and animals suffering from a poxvirus infection. Pharmaceutical compositions for treating poxvirus infected subjects are also provided.
Public/Granted literature
- US20120322770A1 THERAPEUTIC COMPOUNDS FOR BLOCKING DNA SYNTHESIS OF POX VIRUSES Public/Granted day:2012-12-20
Information query
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