Invention Grant
US08524730B2 Spirochromanone carboxylic acids 有权
新型螺环酮羧酸

  • Patent Title: Spirochromanone carboxylic acids
  • Patent Title (中): 新型螺环酮羧酸
  • Application No.: US12997263
    Application Date: 2009-06-29
  • Publication No.: US08524730B2
    Publication Date: 2013-09-03
  • Inventor: Hideki JonaYoshihiro ShibataTakeru Yamakawa
  • Applicant: Hideki JonaYoshihiro ShibataTakeru Yamakawa
  • Applicant Address: JP Tokyo
  • Assignee: MSD K.K.
  • Current Assignee: MSD K.K.
  • Current Assignee Address: JP Tokyo
  • Agent Janet E. Fair; John C. Todaro
  • Priority: JP2008-175229 20080704; JP2009-108704 20090428
  • International Application: PCT/JP2009/062237 WO 20090629
  • International Announcement: WO2010/002010 WO 20100107
  • Main IPC: C07D405/04
  • IPC: C07D405/04 A61K31/438
Spirochromanone carboxylic acids
Abstract:
The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
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